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KOSTURKOVA, M., RADANOVA, M., MIHAYLOVA, G. and KADINOV, V. 2020. RHEUMATOID ARTHRITIS AND THE COMPLEMENT SYSTEM. Revmatologiia (Bulgaria). 28, 4 (Dec. 2020), 45-58. DOI:https://doi.org/10.35465/28.4.2020.pp45-58.


The complement system represents a major part of the immune response. Its normal functioning is mandatory for the organism’s defence against pathogens and for the clearance of immune complexes, apoptotic cells and cellular debris. Its over-activation however can lead to generation of many pro-inflammatory and cytotoxic mediators, causing inflammation and tissue damage. The participation of the complement system in rheumatoid arthritis’(RA) pathogenesis is indisputable but its intimate mechanisms and the opportunities for influencing them are still an object of investigation. The aim of this review is to outline and systematize all the relevant scientific evidence.

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