Osteoarthritis (ОА) is a disease of synovial joints, damaging all the structures of the articular apparatus with a chronic progressive course, resulting in an articular dysfunction. The modern concepts present OA as a “disease of the entire organism” – an active disease process, determined by a group of factors –systemic (genetic, neuro-humoral, hormonal) and local ( biomechanical. These factors are “general” for the development of OA, but of different extent of significance in the different articular locations. In the descriptive review are presented the modern concepts of the role and the interaction between the different factors, concerning the aetiology and pathogenesis of the disease. Also a lot of data, referring to the incidence and prevalence of OA all over the world and in our region are pointed out.
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