Abstract
We present a patient with 5 years systemic sclerosis with diffuse scin manifestations, capillaroscopic data to confirm diagnosis, elevated levels of ANA-antibodys, Anti-Sox-1, Anti-Ro-52 and Anti-Histoni in the course of lung adenocarcinoma (proven by fibrobronchoscopy and biopsy) and brain metastasis in consequence. From the clinical examination it is established diffuse scin manifestations, weakened vesicular respiration in right site of lung, astheno-adynamic syndrome, shortness of breath with usual physical exertion. From lung function testsр FVC is 58% anf FEV1 is 59%. The adenocarcinoma on a wide area in the right half of the lung and not indicated for surgical treatment. Patient was conducted 4 cours of chеmotherapy with Alimta + Cisplatin from marth 2016 г to jull 2016 year, 7 cours Docetaxel from februari 2017 year to septembre 2017 year, radiotherapy. One year later complaints appear from forget of words, hard reading and writing. Computed tomography (CT) shows intracranial tumor formation with heterogeneous structure in left frontal btain half – methastasis after lung adenocarcinoma. Was conducted operative removal of tumoral formation, postoperative radiotherapy and Depakin chrono 2 time for 500 мг daily. The treatment for systemic sclerosis was followed by 8 mg Methylprednisolon and 250 mg Cuprenil with good therapeutic effect.