Abstract

This study aims to assess vitamin D levels in women with postmenopausal osteoporosis and healthy women going through menopause. Two groups of menopausal women took part in the study – 41 women with osteoporosis and 22 without osteoporosis. The levels of vitamin D, parathormone, alkaline phosphatase, calcium and phosphorus were examined during the autumn-winter period. Calcium, phosphorus and alkaline phosphatase were established within the reference range in both groups. A negative correlation with increase of parathormone levels among the patients with osteoporosis and vitamin D deficiency was found (r = -0.46, p<0.01).


16 women with osteoporosis (39%) were with normal levels of vitamin D, 14 (34,1%) were with insufficiency and 11 (26,9%) with deficiency. Within the control group, 8 women (36,4%) were with normal levels of vitamin D, 12 (54,5%) were with  insufficiency and 2 (9,1%) with deficiency.


There is no statistically significant difference in the mean age of patients with normal levels and vitamin D insufficiency in the two groups. There are statistically significant differences in the age of women with vitamin D deficiency. Patients with deficiency were significantly older, both in the osteoporosis group and in the control group (r = -0.32, p <0.05). There are no statistically significant differences in BMD of lumbar spine associated with vitamin D levels in the two groups. There is a significant statistical difference in the average values of BMI in both groups. The average value of BMI in the patients with osteoporosis is 24.2 kg/m2 while in the patients of the control group it’s 29.5 kg/m2 (p<0.0001). The results show an overall bad status of vitamin D. 61% of the patients with osteoporosis and 63,6 % of the healthy controls have levels of vitamin D showing either insufficiency or deficiency.


 


Key words: postmenopausal osteoporosis, insufficiency and deficiency of vitamin D, BMD, BMI