The broad definition of health proposed by the WHO more than 50 years ago states: „Health is a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity.“ Most healthcare providers and professionals have adapted this broad view of health and now include measures for the overall impact of the disease and its treatment. The most common tool used is Short Form-36. SF-36 consists of 36 questions for a multi-purpose study of the patient‘s overall health status developed by the WHO. Aim of study. The aim of the study is to create experimental conditions for selection of healthy volunteers by assessing the health status of pharmacy students through self-assessment of their condition, refracted through the HRQoL tool SF-36, in four main domains: physical, social and behavioral functioning, mental health, and general perceptions of health. Materials and Methods. We interviewed pharmacy students from the Faculty of Chemistry and Pharmacy at Sofi a University “Sv. Kliment Ohridski” using SF-36v2 Questionnaire. The research included 26 students aged between 22 and 25, distributed equally between men and women, after they duly signed an informed consent form and were informed of the conditions for completing the questionnaires. Data is processed statistically with the specifi ed program. Results and Discussion. The results obtained showed serious deviations from the norms of the functioning of the “healthy volunteers” in the four functional domains and posed a number of questions as to how to select control groups of healthy volunteers for randomized controlled clinical trials