Systemic Lupus in males – clinical-laboratory, immunological and histological characteristics.
Vol. 30 No. 3 (2022), Original Articles
Vol. 30 No. 3 (2022)

Systemic Lupus in males – clinical-laboratory, immunological and histological characteristics.: SLE in males

Original Articles
https://doi.org/10.35465/30.3.2022.pp15-20
Published October 17, 2022
Atanas Kundurdjiev
Clinic of Nephrology, University Hospital St. Ivan Rilski, Medical University, Sofia, Bulgaria
Milena Krasimirova Nikolova
Clinic of Nephrology, University Hospital St. Ivan Rilski, Medical University, Sofia
Anna Kostadinova
Clinic of Nephrology, University Hospital St. Ivan Rilski, Medical University, Sofia, Bulgaria
Diyan Genov
Clinic of Nephrology, University Hospital St. Ivan Rilski, Medical University, Sofia, Bulgaria
Maria Hristova
Clinic of Nephrology, University Hospital St. Ivan Rilski, Medical University, Sofia, Bulgaria
Neli Koleva
Clinic of Nephrology, University Hospital St. Ivan Rilski, Medical University, Sofia, Bulgaria
Rada Gancheva
Clinic of Rheumatology, University Hospital St. Ivan Rilski, Medical University, Sofia, Bulgaria
Zlatimir Kolarov
Clinic of Rheumatology, University Hospital St. Ivan Rilski, Medical University, Sofia, Bulgaria
Dobroslav Kiurkchiev
Department of Clinical Immunology, University Hospital St. Ivan Rilski, Medical University, Sofia, Bulgaria
Ekaterina Todorova
Department of Clinical Immunology, University Hospital St. Ivan Rilski, Medical University, Sofia, Bulgaria
Dimitar Monov
Intensive care unit, University Hospital St. Ivan Rilski, Medical University, Sofia, Bulgaria
Kalina Chupetlovska
Intensive care unit, University Hospital St. Ivan Rilski, Medical University, Sofia, Bulgaria
Todor Todorov
Department of Clinical Pathology, Medical University, Sofia, Bulgaria
Violina Minkova
Department of Clinical Pathology, Medical University, Sofia, Bulgaria
Julian Ananiev
Department of General and Clinical Pathology, Medical Faculty, Trakia University, Stara Zagora, Bulgaria
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Kundurdjiev et al. PDF (BG) (Български)

Keywords

systemic lupus, lupus nephritis, antiphospholipid syndrome, male, clinical characteristics, autoantibodies, treatment

How to Cite

Kundurdjiev, A., Nikolova, M., Kostadinova, A., Genov, D., Hristova, M., Koleva, N., Gancheva, R., Kolarov, Z., Kiurkchiev, D., Todorova, E., Monov, D., Chupetlovska, K., Todorov, T., Minkova, V., & Ananiev, J. (2022). Systemic Lupus in males – clinical-laboratory, immunological and histological characteristics. Rheumatology (Bulgaria), 30(3), 15-20. https://doi.org/10.35465/30.3.2022.pp15-20
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Abstract

Systemic lupus erythematosus is a chronic, systemic, non-organ-specific autoimmune disease that affects all organs and systems of the human body and is characterized by the production of autoantibodies against nuclear antigens. Its prevalence in Europe reaches 1:2500. It affects mostly women (female : male ratio=9 : 1) in fertile age group (15-45 years). The clinical course of lupus in males is characterized by more aggressive clinical course and the development of serious complications, such as vasculitis, central nervous system involvement, antiphospholipid syndrome, etc. For the period of 7 years (2012-2019) we observed overall 18 male patients with systemic lupus, 11 with biopsy-proven renal involvement and 7 without clinically significant renal disease (proteinuria < 0.5 g/24 h., no erythrocyturia/cylindruria, normal renal function), mean age at the diagnosis 39.6 +/- 12.3 years. All patients received pathogenetic treatment (corticosteroids + cytotoxic agents). Three had secondary antiphospholipid syndrome, 1 – inflammatory bowel disease, 1 – seronegative spondyloarthropathy. Three had type 2 diabetes. The authors discuss the clinical, immunological and histological characteristics and the therapeutic approach in males with systemic lupus.  

https://doi.org/10.35465/30.3.2022.pp15-20
Kundurdjiev et al. PDF (EN)
Kundurdjiev et al. PDF (BG) (Български)

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