Evaluation of Metabolic Syndrome in Egyptian Patients with Radiographic and Non-Radiographic Axial Spondyloarthritis (Cross Sectional Study)
PDF

Keywords

Metabolic syndrome, Radiographic, Non-Radiographic Axial spodyloarthritis.

How to Cite

Gado, S., Elwan, S., El Sharkawy, A., & El-Banna, H. (2022). Evaluation of Metabolic Syndrome in Egyptian Patients with Radiographic and Non-Radiographic Axial Spondyloarthritis (Cross Sectional Study). Rheumatology (Bulgaria), 30(2), 28-34. https://doi.org/10.35465/30.2.2022.pp53-59

Abstract

Background: Axial spondyloarthritis is a chronic inflammatory rheumatic disease that has a great risk for metabolic syndrome. Our aim was to study metabolic syndrome (MetS) in radiographic and non- radiographic axial spondyloarthritis patients in Egyptian population. Methods: The cross-sectional study included 60 consecutive Ax-SpA patients aged 25-55 years fulfilling the Assessment of Spondyloarthritis International Society criteria; they were divided into 40 patients with radiographic and 20 patients with non- radiographic axial spodyloarthritis. MetS was assessed using new international diabetes federation definition. Results: The prevalence of MetS was higher in radiographic patients (37.50%) than non-radiographic axial spondyloarthritis (20%) (X2 = 0.170, P = 0.242) with significant differences between the two groups as regard triglycerides (p = 0.012*) and HDL cholesterol (p < 0.001*). Decreased HDL-cholesterol was the most frequent metabolic syndrome component with a prevalence of 66.66% (40 patients) in both groups. Conclusion: Metabolic syndrome was more prevalent in radiographic axial spodyloarthritis. Therefore, follow up of these patients is important for early detection of any cardiovascular events.

https://doi.org/10.35465/30.2.2022.pp53-59
PDF

References

  1. Mease PJ, Heijde DV, Karki C, Palmer JB, Liu M, Pandurengan R, Park Y, Greenberg JD. Characterization of Patients With Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis in the US‐Based Corrona Registry. Arthritis care & research. 2018;70(11):1661-70.
  2. Hong C, Kwan YH, Leung YY, Lui NL, Fong W. Comparison of ankylosing spondylitis and non‐radiographic axial spondyloarthritis in a multi‐ethnic Asian population of Singapore. Int J Rheum Dis. 2019;22(8):1506-11.
  3. Poddubnyy D, Sieper J. Similarities and dif-ferences between nonradiographic and radio-graphic axial spondyloarthritis: a clinical, epi-demiological and therapeutic assessment. Curr Opin Rheumatol. 2014; 26: 377-83.
  4. Baraliakos X, Braun J. Non-radiographic axial spondyloarthritis and ankylosing spondylitis: what are the similarities and differences? RMD open. 2015 1;1(1): e000053.
  5. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F; American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005;112(17):2735-52.
  6. Devaraj S, Rosenson RS, Jialal I. Metabolic syndrome: an appraisal of the pro-inflammatory and procoagulant status. Endocrinology and metabolism clinics of North America. 2004;33(2):431-53.
  7. Betts KA, Griffith J, SongY, Mittal M, Joshi A,Wu EQ et al (2016) Network meta-analysis and cost per responder of tumor necrosis factor-α and interleukin inhibitors in the treatment of active ankylosing spondylitis. Rheumatol Ther 3:323–336
  8. Jialal I. The role of the laboratory in the diagnosis of the metabolic syndrome. Am J Clin Pathol. 2009;132(2):161-2
  9. Raychaudhuri SK, Chatterjee S, Nguyen C, Kaur M, Jialal I, Raychaudhuri SP. Increased prevalence of the metabolic syndrome in patients with psoriatic arthritis. Metab Syndr Relat Disord. 2010;8(4):331-4.
  10. Rudwaleit, M, van der Heijde D, Landewe R, List-ing J, Akkoc N, Brandt J, et al. The development of Assessment of SpondyloArthritis international Society classification criteria for axial spondyloar-thritis (part II): validation and final selection. Ann Rheum Dis. 2009; 68: 777-83.
  11. Saif-Ali, R., Kamaruddin, N.A., AL-Habori, M. et al. Relationship of metabolic syndrome defined by IDF or revised NCEP ATP III with glycemic control among Malaysians with Type 2 Diabetes. Diabetol Metab Syndr. 2020; 12(1), 1-7.
  12. Van der Heijde D, Lie E, Kvien TK, Sieper J, Van den Bosch F, Listing J, et al. ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosing spondylitis. Ann Rheum Dis. 2009; 68: 1811-8.
  13. Ramiro S, van Tubergen A, Stolwijk C, Landewé R, van de Bosch F, Dougados M, van der Heijde D. Scoring radiographic progression in ankylosing spondylitis: should we use the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) or the Radiographic Ankylosing Spondylitis Spinal Score (RASSS)? Arthritis Res Ther. 2013 Jan 17;15(1):R14
  14. Sidiropoulos PI, Karvounaris SA, Boumpas DT. Metabolic syndrome in rheumatic diseases: epidemiology, pathophysiology, and clinical implications. Arthritis Res Ther. 2008;10(3):207.
  15. Kiltz U, Baraliakos X, Karakostas P, Igelmann M, Kalthoff L, Klink C, Krause D, Schmitz‐Bortz E, Flörecke M, Bollow M, Braun J. Do patients with non‐radiographic axial spondylarthritis differ from patients with ankylosing spondylitis? Arthritis care & research. 2012 Sep;64(9):1415-22.
  16. Emren SV, Gerçik O, Özdemir E, Solmaz D, Eren N, Şimşek EÇ, Tokaç M, Emren Z, Kabadayı G, Akar S. Evaluation of subclinical myocardial dysfunction using speckle tracking echocardiography in patients with radiographic and non-radiographic axial spondyloarthritis. European Journal of Rheumatology. 2020 Jan;7(1):9.
  17. Poddubnyy D, et al. Brief report: clinical course over two years in patients with early nonradiographic axial spondyloarthritis and patients with ankylosing spondylitis not treated with tumor necrosis factor blockers: results from the German Spondyloarthritis Inception Cohort. Arthritis Rheumatol. 2015;67(9): 2369–75.
  18. de Winter JJ, van Mens LJ, van der Heijde D, Landewé R, Baeten DL. Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis. Arthritis Res Ther. 2016 Sep 1;18(1):196.
  19. Malaviya AN, Kalyani A, Rawat R, Gogia SB. Comparison of patients with ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA) from a single rheumatology clinic in New Delhi. Int J Rheum Dis. 2015 Sep;18(7):736-41.
  20. Liu M, Huang Y, Huang Z, Huang Q, Guo X, Wang Y, Deng W, Huang Z, Li T. Prevalence of metabolic syndrome and its associated factors in Chinese patients with ankylosing spondylitis. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2019; 12:477.
  21. Malesci D, Niglio A, Mennillo GA, Buono R, Valentini G, La Montagna G. High prevalence of metabolic syndrome in patients with ankylosing spondylitis. Clinical rheumatology. 2007 May 1;26(5):710.
  22. Gunawan H, Mudjanarko SW, Awalla LD, Soeroso J, Pranoto A. Correlation Of Radiographic Damage And Metabolic Syndrome In Spondyloarthritis: A Cross-Sectional Study.2019
  23. Betancur G, Orozco M, Schneeberger E, Lizarraga A, Zamora N, Sommerfleck F, Citera G. Prevalence of Obesity and Metabolic Syndrome in Patients with Axial Spondyloarthritis: Abstract Number: 1704. Arthritis & Rheumatology. 2015; 67:2095-6.
  24. Maia DG, Augusto KL, Bezerra MC, Rodrigues CEM. Metabolic syndrome in patients with ankylosing spondylitis receiving anti-TNFα therapy: Association with predictors of cardiovascular risk. Clin Rheumatol. 2017; 36:2371-6.
  25. Papadakis JA, Sidiropoulos PI, Karvounaris SA, Vrentzos GE, Spanakis EK, Ganotakis ES, et al. High prevalence of metabolic syndrome and cardiovascular risk factors in men with ankylosing spondylitis on anti-TNFalpha treatment: Correlation with disease activity. Clin Exp Rheumatol. 2009; 27:292-8.
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Downloads

Download data is not yet available.